G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotores: J.N. Kok, H.J. Hoogeboom

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

Promotores: P. Stevenhagen, A. Enge Co-Promotor: T.C. Streng

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Electron microscopy has become an extremely important techniquein a wide variety of elds.

In my research, I used a comparative wood anatomical approach to address wood evolution of the (largely) tropical flowering plant families Apocynaceae and Sapotaceae.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

This thesis utilises the exceptional sensitivity and resolution of LOFAR to explore the low-frequency Universe, while simultaneously advancing the telescope's capabilities to enable new scientific discovery.

Promotor: J. A. Bouwstra

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Promotor: Prof.dr. H.J.A. Rottgering

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.

Deelproject van

Supervisor: P.J.J. Hooykaas

An interdisciplinary collection of the best international scholarship on Muslim youth.

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

Lezing

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

In het collectieve geheugen is lang hard geoordeeld over de Joodse Raad. Dat beeld behoeft bijstelling, beargumenteert universitair docent Bart van der Boom in zijn nieuwe boek ‘De politiek van het kleinste kwaad’.

Congres/symposium

The Leiden University Centre for Digital Humanities has awarded some small research grants to foster the developments of new digital research. These projects began in February 2018. On the 9th of October, these awardees will present their work, along with our PhD students.

Bij kraken denk je waarschijnlijk aan jongeren in de grotere steden van Nederland. Ook Leiden kent een kraakgeschiedenis, en die geschiedenis is zeer divers.

Volume 72 of the Netherlands Yearbook for History of Art is dedicated to the relationship of art and death in the Low Countries and its diaspora, from premodern times to the present. The editors welcome contributions on works of art and architecture (paintings, prints, sculptures, objects of applied…

De polarisatie in onze samenleving neemt toe. Waardoor worden mensen steeds radicaler? Hoe beschermen we onszelf tegen extremistische, terroristische of criminele dreiging, of deze nu fysiek of in de cyberwereld speelt? En welke rol spelen inlichtingendiensten hierin?

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

In this project of the Center for Public Values & Ethics (CPVE) ongoing research is conducted on the history of advice to Dutch central government by so-called State committees from 1814 to 2014. State committees have been installed by Dutch central government since 1814 to provide expert advice, research…

This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.