This thesis consists of two subjects, that are both a consequence of radiation pressure.

Lezing, Unfolding Finitudes

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

A History of Dutch Corruption and Public Morality toont 300 jaar verandering, continuïteit en diversiteit in de geschiedenis van Nederlandse politieke corruptie en publieke moraliteit. Het analyseert een reeks corruptieschandalen en toont hoe de debatten daarover waren verbonden met de grote veranderingen…

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Voor de omzetting van zonlicht naar brandstof

hotocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Overkleeft

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Homohuwelijk, draagmoederschap, abortus. Hoe reageert het recht op dergelijke moreelgevoelige onderwerpen bij grensoverschrijdend verkeer binnen de Europese Unie? Op 4 november 2015 promoveert Nelleke Koffeman op dit onderwerp.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Promotie

Alle aanmeldingen worden beoordeeld door de Toelatingscommissie van het ICLON. De Toelatingscommissie doet een uitspraak over je toelaatbaarheid.

Congres/symposium

Nieuw onderzoek van de National University of Singapore en Leiden laat zien dat chimpansees en bonobo’s net zoveel contrast in hun ogen hebben als mensen, waardoor ze gemakkelijk de richting van iemands blik kunnen volgen.

We found that, next to the effectiveness of the intervention, it’s also very likely that the intervention is cost-effective compared to attention only.

Docenten spelen een cruciale rol bij het implementeren van onderwijsvernieuwingen. Uiteindelijk hangt het succes van de implementatie af van de manier waarop docenten de vernieuwing vormgeven in hun dagelijkse lespraktijk.

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

Promotie

Europese burgers worden geconfronteerd met uitdagingen op het gebied van globalisering, migratie, technologische ontwikkelingen en klimaatverandering. Deze uitdagingen vergen het uiterste van onderlinge internationale en intergenerationele solidariteit, wat rechtstreeks betrekking heeft op de grondslagen…

World history is often framed in terms of flows of people and migration: humans coming ‘out of Africa’, the spread of farmers in the Holocene, Phoenician and Greek diasporas over the ancient Mediterranean, the colonization of the world by Europeans from the 16th century onwards. Together with his Exeter…

Het masterprogramma is officieel geopend door Z.E. Kees Klompenhouwer, de Nederlandse Ambassadeur in Tsjechië.

Snelle en goedkope chips die extreem kleine hoeveelheden vloeistof (microfluïden) analyseren vormen de kern van gepersonaliseerde gezondheidszorg. Maar het ‘laboratorium op een chip’ is nog niet effectief genoeg. Dr. Paul Vulto en zijn onderzoeksteam ontwikkelden een techniek die het gebruik van microfluïdische…

The Titus Brandsma Institute and Radboud University Nijmegen organize an international conference on Thursday 19 and Friday 20 August 2021: Thomas a Kempis, his Works and their Reception.

Samen met mevrouw A. Roper en mevrouw L. Wang heeft prof.dr. J.I. van der Rest een artikel in het tijdschrift 'International Journal of Hospitality Management' gepubliceerd.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.