Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Promotor: J. Aarts

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Promotor: R. Cramer

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotor: W.T. de Groot

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Supervisor: P.J.J. Hooykaas

Globally and regionally, biodiversity is declining and there are shifts in species’ occurrences and functional traits.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

This thesis deals with properties of Jacobians of genus two curves that cover elliptic curves.

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

In this thesis, we study different curved single crystals because of the diversity of surface structures across their curvature.

This dissertation presents new cryptographic protocols, which can be divided into two families.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

Plastics have become an integral part of modern society due to their versatility and durability.

The thesis is about how auxin and AGC kinases regulate male fertility. The main AGC kinases studied in this thesis is PDK1, PDK2 and AGC1.5, AGC1.7.

Participants in this course will learn to support student teachers and new colleagues in their professional development as teachers, with particular emphasis on the context of bilingual or international education, as in the ICLON World Teachers Programme (WTP).

De leesvaardigheid van Nederlandse jongeren daalt al jaren. De voornaamste oorzaak voor die afname is dat veel leerlingen moeite hebben met verdiepend lezen. Leer leerlingen om teksten actief te lezen, en om zo bezig te zijn met het construeren van betekenis. Dat schrijven de Leidse onderzoekers Paul…

Als een kind of jongere in familiaire kring gewoon praat, maar niet of nauwelijks spreekt wanneer anderen in de buurt zijn, kan er sprake zijn van selectief mutisme. Dit valt vooral op wanneer kinderen niet spreken met leerkrachten en/of leeftijdsgenoten. In dit boekje krijg je handvatten om erg stille…

Het onderzoek van het Brain and Education Lab richt zich op de ontwikkeling van cognitieve processen die betrokken zijn bij leren en academische vaardigheden zoals begrijpend lezen, wiskunde en ruimtelijke vaardigheden. Daarbij richt het onderzoek zich specifiek op één van de meest opwindende fasen…

Op vrijdag 13 februari 2026 neem je deel aan de eerste selectieronde. Deze vindt plaats in het Universitair Sportcentrum in Leiden (de tentamenlocatie van Universiteit Leiden). Praktische informatie hierover ontvang je begin februari.

Het team van wetenschappers binnen TRIXY zorgt ervoor dat er belangrijke kennis verzameld wordt over kwetsbaarheden bij deze kinderen, met name op het gebied van de cognitieve, emotionele, en sociale ontwikkeling, in relatie tot risico op gedragsproblemen.

Het Brain and Education lab is een onderzoeksgroep van het Instituut Pedagogische Wetenschappen aan de Universiteit Leiden en maakt deel uit van het Leiden Institute for Brain and Cognition (LIBC). Ons onderzoek richt zich op de ontwikkeling van cognitieve processen die betrokken zijn bij leren en academische…

Neurobiologische mechanismen van emotieregulatie

Op vrijdag 13 februari 2026 neem je deel aan de eerste selectieronde. Deze vindt plaats in het Universitair Sportcentrum in Leiden (de tentamenlocatie van Universiteit Leiden). Praktische informatie hierover ontvang je begin februari.

Op 1 juli 2020 verdedigde Niek Strohmaier zijn proefschrift 'Making Sense of Business Failure'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.A.A. Adriaanse en dr. H. Pluut.