While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Promotor: Prof.dr. G.R. de Snoo

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

Breast cancer (BC) is a clinically and biologically heterogeneous disease.

Om je aan te melden voor de bacheloropleiding Molecular Science and Technology heb je meerdere documenten nodig. Zorg ervoor dat je deze documenten bij de hand hebt.

Leidse chemisch biologen, onder leiding van dr. Mario van der Stelt, hebben een methode ontwikkeld om de zoektocht naar nieuwe geneesmiddelen te versnellen. Met deze methode is het hen al gelukt om een belangrijke eerste stap te zetten in de ontwikkeling van een medicijn tegen obesitas.

Een overzicht van awards en prijzen die in 2020 zijn toegekend aan onze medewerkers en studenten, maar ook bijzondere benoemingen aan de Universiteit Leiden en andere instellingen.

De missie van het Plant Sciences onderzoeksprogramma is om bij te dragen aan de duurzame productie van gewassen van hoge kwaliteit, bloemen en hoogwaardige producten met een biologische basis. Dit wordt gerealiseerd door het opdoen van fundamentele kennis over biologische processen omtrent de ontwikkeling…

Design and synthesis of two 3-substituted swainsonine derivatives with the aim to improve the potency and selectivity towards Golgi alpha-mannosidase II.

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

Wij voeren multidisciplinair onderzoek uit op het niveau van moleculen, cellen en organismen binnen de dierkunde. Ons doel is om fundamentele kennis te vergroten over gezondheid en ziekte.

In deze opleiding streef je naar het beantwoorden van biologische vraagstukken in relatie tot milieu, ecologie en andere maatschappelijk relevante onderwerpen.

In het onderzoeksprogramma Microbial Biotechnology voeren wij vernieuwend onderzoek uit in de biotechnologie en microbiologie.

In het onderzoeksprogramma Microbial Biotechnology voeren wij vernieuwend onderzoek uit in de biotechnologie en microbiologie.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.

Celebrating 20 years of Environmental Research and Education in Northern Cameroon

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

Oratie

Maar liefst 1300 internationale studenten van 84 verschillende nationaliteiten leren in de Orientation Week Leiden de universiteit en elkaar kennen. Waar komen ze vandaan en waarom kozen ze voor Leiden?

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

During the course of drug discovery translational steps are made.

Understanding how chemical complexity emerges during star formation requires connecting molecular material preserved in interstellar ices with that observed in the gas phase after protostellar heating begins.

Promotie

Twee jonge excellente chemici, Jeroen Codée en Sander van Kasteren, hebben een ECHO subsidie van € 260.000 euro toegekend gekregen door de Nederlandse Organisatie voor Wetenschappelijk Onderzoek. Hiermee kunnen hun onderzoeksprojecten van start gaan.