Wereldwijd zijn er ruim 7000 talen; meer dan de helft van de wereldbevolking is meertalig. Maar hoe gebruiken al die mensen hun taal? En op welke vlakken verschillende deze taken van elkaar? Onder het motto ‘Interconnecting linguistic diversity’ zijn de onderzoekers van het Leiden University Centre…

Gedeelde identiteit, de vorming van onze jeugd en toekomst, ontwikkeling van wetenschap en techniek: over zulke gevoelige onderwerpen gaat het in het onderzoek naar 100 jaar Ministerie van Onderwijs, Cultuur en Wetenschap (OCW).

We verwelkomen gastwetenschappers wier onderzoek aansluit bij onze uiteenlopende expertisegebieden. De tekst gaat verder in het Engels.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Met ons onderzoek en onderwijs dragen we bij aan een betere wereld. We mengen ons in het wetenschappelijke en publieke debat, en zoeken antwoorden voor economische en maatschappelijke vraagstukken. Zowel lokaal en regionaal als mondiaal.

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

In this thesis,

Promotor: Prof.dr. S. Haring

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: Prof.dr. A.G.G.M. Tielens

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: P.D. Grünwald

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

A new publication on changes in the relationship between news and their public in Chile

Promotor: Prof.dr. C.W.J. Beenakker

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Cardiovascular syndromes are the major cause of death in Western societies.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

In this work, I explore the creation of new methods that optimize simulations of the gravitational N-body problem. Specifically, I take advantage of the recent popularity of Machine Learning methods to find tools that can suit this problem.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotor: Prof.dr. D. Bouwmeester

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.