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3,975 zoekresultaten voor “leiden teachers academic” in de Publieke website

• Multifunctional polypept(o)ide miktoarm star polymers for advanced drug delivery: from the development of versatile synthetic strategies for Onderzoeksoutput

  With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

• Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis Onderzoeksoutput

  In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

• The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation Onderzoeksoutput

  Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

• Electroextraction approaches for preconcentration of metabolites Onderzoeksoutput

  In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.

• Statistical learning for complex data to enable precision medicine strategies Onderzoeksoutput

  Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

• Transforming data into knowledge for intelligent decision-making in early drug discovery Onderzoeksoutput

  Promotor: A.P.IJzerman Co-promotor: A. Bender

• Capillary Electrophoresis-Mass Spectrometry based Metabolomics Approaches for Volume-restricted Applications Onderzoeksoutput

  Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

• It's about time Onderzoeksoutput

  This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

• Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research Onderzoeksoutput

  Cardiovascular diseases are still a major concern for the global health.

• Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor Onderzoeksoutput

  During the course of drug discovery translational steps are made.

• Proteins in harmony: Tuning selectivity in early drug discovery Onderzoeksoutput

  This thesis describes the importance of being able to control the selectivity of potential drug candidates.

• To affinity and beyond: novel molecular tools to explore solute carrier transport proteins Onderzoeksoutput

  Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

• The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis Onderzoeksoutput

  In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

• High-throughput quantification and unambiguous identification for metabolomics Onderzoeksoutput

  The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

• Identification of novel targets in prostate cancer progression Onderzoeksoutput

  Promotor: B. van de Water, Co-promotor: E.H.J. Danen

• Adjuvanted nanoparticulate seasonal influenza vaccines Onderzoeksoutput

  Promotor: W. Jiskoot, Co-promotor: A. Kros

• Innovative sample preparation and handling strategies for automated and high-throughput metabolomics Onderzoeksoutput

  Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

• Dynamics of TNFalpha signaling and drug-related toxicity Onderzoeksoutput

  In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

• The flux and flow of data: connecting large datasets with machine learning in a drug discovery envirionment Onderzoeksoutput

  This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

• Governance Dossier: Una Europa

• Onderzoeksfaciliteiten

• The academic I meant to be Agenda - 23 mei 2025

  Oratie

• Prestigieuze Journal of European Public Policy selecteert Leids onderzoek voor Special Issue Nieuws - 4 april 2017

  Het Journal of European Public Policy heeft de Special Issue dit jaar gewijd aan het thema European Union Enlargement and Integration Capacity, op voordracht van dr. Antoaneta Dimitrova, universitair hoofddocent van het instituut Bestuurskunde van de Universiteit Leiden. In de Special Issue zijn bovendien…

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  Rüya Koçer Universitair hoofddocent

  Faculteit der Sociale Wetenschappen

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  Ana Parrón Cabañero Promovendus

  Faculteit der Sociale Wetenschappen

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  Willemijn Plomp Data steward

  Faculteit der Sociale Wetenschappen

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  Jaap-Willem Mink Data Steward

  Faculteit der Sociale Wetenschappen

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  Agnes Schneider Promovendus

  Faculteit Archeologie

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  Maximilian König Promovendus / gast

  Faculteit der Sociale Wetenschappen

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  Chris Verhoeven Universitair docent

  Faculteit der Sociale Wetenschappen

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  Olga Ceran Onderzoeker

  Faculteit Rechtsgeleerdheid

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  Zohreh Zahedi Gastonderzoeker

  Faculteit der Sociale Wetenschappen

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  Leticia Rettore Micheli Assistant professor

  Faculteit der Sociale Wetenschappen

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  V. Nespeca Postdoc

  Faculteit Governance and Global Affairs

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  Ruthie Pliskin Universitair docent

  Faculteit der Sociale Wetenschappen

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  Alysa Eijkelenboom Promovendus

  Faculteit Governance and Global Affairs

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  Katie Hudson Data Steward/Onderzoek ondersteuner

  Faculteit der Sociale Wetenschappen

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  Aleksandrina Skvortsova Universitair docent

  Faculteit der Sociale Wetenschappen

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  Sander van Rijn Promovendus

  Wiskunde en Natuurwetenschappen

• AFITE Europa Instituut

  Het fundamentele recht op ‘vrijheid van de kunsten en het wetenschappelijk onderzoek’ in de EU: een verkenning van de grenzen van de commercialisering van de academie (AFITE).

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  Lisann Brincker Medewerker onderwijsontwikkeling

  Wiskunde en Natuurwetenschappen

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  Wybrigje de Vries Medewerker onderwijsontwikkeling

  Wiskunde en Natuurwetenschappen

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  Marit Postma Supportmedewerker ICT en Onderwijs bij SEEDS

  Wiskunde en Natuurwetenschappen

• Samenwerken voor efficiënte medicijnontwikkeling Wetenschapsdossier

  De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap, tot klinische tests, tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…

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  Javad Hayatdavoudi Promovendus

  Faculteit der Sociale Wetenschappen

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  Andrew Hoffman Service Scientist - Research Data Management

  Faculteit der Sociale Wetenschappen

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  Francesca Arici Universitair docent

  Wiskunde en Natuurwetenschappen

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  Céline Richard Datamanager

  Faculteit der Sociale Wetenschappen

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  Joyce Snijdewint Promovendus

  Faculteit der Sociale Wetenschappen

• Armin Cuyvers Dossier: Leiden Teachers’ Academy

  Van onderwijs tot een verrijkende ervaring