Machine Learning is becoming a more and more substantial technology for industry.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

Dit onderzoek richt zich op het proces waarmee docenten eigen lespraktijk stapsgewijs kunnen aanpassen in de richting van activerende didactiek en gedifferentieerd onderwijs.

In vroegmiddeleeuws Engeland was er belangstelling voor de geschiedenis van het Romeinse Rijk en koningen namen imperiale titels als 'imperator' en 'basileus' over. Hoe kunnen we deze interesse verklaren en welke functies hadden imperiale ideeën en de ontvangst van de klassieke wereld in vroegmiddeleeuws…

Welke relatie bestaat er tussen verschillende type PLGs en cognitieve differentiatie?

Enkele van de belangrijkste handschriftencollecties uit de Bijzondere Collecties van de Universitaire Bibliotheken Leiden (UBL), bestaande uit 443 uiterst zeldzame en vaak unieke banden, zijn in Open Access beschikbaar gesteld via Digital Collections. De beschikbare handschriftcollecties omvatten de…

In deze publicatie worden problemen met betrekking tot de grensoverschrijdende afwikkeling van financiële instellingen onderzocht.

De Faculteit der Rechtsgeleerdheid deelt met trots mee dat Professor Ann Skelton, hoogleraar Kinderrechten in een duurzame wereld en voorzitter van het Kinderrechtencomité van de Verenigde Naties, een eredoctoraat is toegekend door de University of Strathclyde. Deze prestigieuze erkenning is een eerbetoon…

Second-year MIRD students showcase their thesis research on global issues during the 2025 Thesis Symposium, bridging theory and diplomatic practice.

Op donderdag 17 oktober organiseerde de masteropleiding Crisis and Security Management (CSM) een informatief alumni-panel met vijf afgestudeerden uit verschillende cohorten. Het panel bood huidige studenten de kans om te luisteren naar professionals die hun eigen weg hebben gebaand in crisis- en vei…

Ben jij geinteresseerd om Bede Sheppard, Human Rights Watch’s Deputy Director of the Children’s Rights Department te ontmoeten? Bede zal donderdag 26 mei voor het #WatchOurSchools evenement in het Auditorium van Anna van Bueren zijn, en wij geven hierbij onze studenten de kans om hem van tevoren te…

ISGA in Den Haag biedt bachelor- en masteropleidingen, minoren en onderzoek in security studies, cybersecurity, terrorisme, diplomatie en actuele veiligheidsvraagstukken. Focuspunten: bachelor, master, minoren, onderzoek, security studies, cybersecurity, terrorisme, diplomatie, veiligheidsvraagst…

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

The name ‘Jambi flora’ refers to fossil plants found as part of a rock formation from the Early Permian (296 million years old), located in the Jambi Province of Sumatra, Indonesia.

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

We willen allemaal een wereld waarin individuen veilig zijn, conflicten vreedzaam worden beslecht en rekening wordt gehouden met toekomstige generaties. Juristen van de Universiteit Leiden onderzoeken in hoeverre het internationaal publiekrecht voorziet in de behoeftes van een geglobaliseerde samenleving.…

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

The Abbey Library of Saint Gall and the Chair for Mediaeval and Renaissance Latin at Friedrich-Alexander-University Erlangen-Nuremberg organize their third Summer School Medieval Writing Culture (V to XV century), which will be held from 16 till 20 May 2022. Deadline for applications: 3 March 2022.

This thesis contains results on the arithmetic and geometry of del Pezzo surfaces of degree 1.In Chapter 1 we give the necessary background, assuming the reader is familiar with algebraic geometry.

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Hot rocky exoplanets are planets that orbit so close to their host star that they possess a molten surface.

Promotor: H.J.M. de Groot

Kunst en vrije tijd, Kunst en vrije tijd

Promotor: Prof.dr. L.J. Slikkerveer

This article 'Shaping the European External Action Service and its post-Lisbon crisis management structures: an assessment of the EU High Representatives’ political leadership' assesses the role, influence and core aspects of the EU High Representatives’ (HR/VPs) “political leadership” in the context…

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

The radio sky harbours both galactic and extragalactic sources of arcminute- to degree-scale emission of various physical origins. To discover extragalactic diffuse emission in the Cosmic Web beyond galaxy clusters, one must image low–surface brightness structures amidst a sea of brighter compact fore-…