Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

Promotor: Prof.dr. H.A.G. Wijshoff

Promotores: H.W. Lenstra, A. Lucchini

Stress komt veel voor in de huidige samenleving. Dit is zorgwekkend, aangezien onderzoek herhaaldelijk heeft aangetoond dat stress een negatieve invloed heeft op de lichamelijke gezondheid. Zo vergroot stress bijvoorbeeld de kans op hart- en vaatziekten.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Dirk Broekhuijsen is op donderdag 16 november 2017 gepromoveerd op zijn proefschrift ‘A multilateral tax treaty: designing an instrument to modernise international tax law’. Zijn promotoren zijn prof. mr. F.A. Engelen en prof. mr. S.C.W. Douma.

Hieratic Papyrology

Mapping the neural mechanisms underlying social motivations of adolescents and adults

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Irene Khan, expert op het gebied van mensenrechten, werpt een aantal vragen op: Wat kan men verstaan onder een ‘Culture of Justice’? Wie bepaalt wat 'Justice' is? Hoe realistisch is de bevordering van ‘Rule of Law’ en ‘Justice’ in landen waar sprake is van ernstige conflictsituaties en armoede?

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Within the field of astronomy, understanding how galaxies grow and evolve from the Big Bang to the present day is a challenging and complex question.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

A key step in the synthesis of oligosaccharides and glycoconjugates is the formation of the glycosidic bond.

Promotores: W. Jiskoot, F. Ossendorp

Did the Jochids leave their mark on the Grand Duchy, taking into account that the Lithuanian state was one of the main successor states of the Great Horde in the 16thCentury?

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

Op dinsdag 24 maart is het boek 'The European Public Servant: A shared Administrative Identity?' verschenen.

Studievoorlichting

Het boek gaat in op de vraag: Hoe en waarom raken mensen betrokken bij het Europese 'homegrown jihadisme'?

Congres/symposium

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

Een internationaal team onder leiding van Leidse sterrenkundigen heeft ontdekt waardoor de twee sterren van dubbelster DI Herculis zo bizar om elkaar heen bewegen. In een artikel in Nature verklaren ze de rare baanbewegingen die zelfs voor Einsteins relativiteitstheorie een probleem vormden.

De minor Creative Strategies for a Society in Change (CSSC) legt een verbinding tussen het verkrijgen van inzicht in creatieve maakprocessen en het verkennen van maatschappelijke problematieken die kenmerkend zijn voor onze tijd.

Kunst en vrije tijd, Kunst en vrije tijd

Studievoorlichting

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Promotor: Prof.dr. J.N. Kok

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.