De Faculteit der Wiskunde en Natuurwetenschappen heeft verschillende studieverenigingen, die zowel studiegerelateerde als sociale activiteiten organiseren voor studenten.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

De nieuwbouw voor de Faculteit der Wiskunde en Natuurwetenschappen is een belangrijke mijlpaal voor de Universiteit Leiden en de faculteit in het bijzonder. In drie fasen wordt een nieuw gebouw gerealiseerd. De eerste fase van het nieuwe gebouw is in 2016 in gebruik genomen en beslaat 45.000m2. Het…

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Leidse milieuwetenschappers doen onderzoek naar microplastics, bestrijdingsmiddelen en bemesting. En binnenkort naar lichtvervuiling en nieuwe materialen uit de nanotechnologie.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Natural history collections provide invaluable sources for researchers with different disciplinary backgrounds, aspiring to study the geographical distribution of flora and fauna across the globe as well as other evolutionary processes.

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

De Faculteit der Wiskunde en Natuurwetenschappen is gevestigd op verschillende locaties in het Bio Science Park Leiden.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

Op dit deel van de website kunt u meer informatie vinden over de Oude Sterrewacht en de huidige faculteit sterrenkunde.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

De Universiteit Leiden streeft naar impact van haar onderzoek en onderwijs op de samenleving. Veel van onze onderzoekers werken daarom samen met academische en maatschappelijke partners, overheidsinstellingen, non-gouvernementele organisaties en het bedrijfsleven.

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

The Study Information Committee works to create a positive and accurate picture of the bachelor and master programs offered by the Institute of Biology Leiden (IBL). The committee consists of IBL staff members and study ambassadors. We reach out to future and current students, high school biology teachers,…

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Met ons onderzoek willen we zowel de wetenschappelijke kennis als de praktische inzichten op het gebied van duurzaamheidsbestuur versterken, en tegelijkertijd een betekenisvolle bijdrage leveren aan het publieke debat over deze urgente vraagstukken. Om dit te bereiken, omarmen we diversiteit in onze…

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Ben jij nieuwsgierig waarom mensen doen wat ze doen en naar de wetenschap erachter? Is intelligentie aangeboren of kun je dat trainen? Hoe kies je je vrienden? Waarom worden mensen depressief en wat is daar aan te doen? Waarom herkent je opa met Alzheimer je niet meer? Psychologen bestuderen dergelijke…

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.