Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…

Promotor: Prof.dr. G.P. van Wezel

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

In het onderwijs bieden wij alle studenten de mogelijkheid om kennis te maken met duurzaamheidsthema’s en –vraagstukken, waar mogelijk aansluitend bij de inhoud van hun opleiding.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

Cardiovascular syndromes are the major cause of death in Western societies.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Heart failure is a major health care problem with high mortality.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

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Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.

In deze bundel wordt verslag gedaan van onderzoek op het gebied van duurzaamheid, uitgevoerd aan de Leidse rechtenfaculteit.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

M. Danhof, Co-promotores: J. Freijer, A. Yassen

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

Promotor: T. H. Oosterkamp

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

Lezing

Recentelijk is een Special Issue van de European Journal of Criminology verschenen, die is samengesteld door Marieke Liem, Universitair Docent Criminologie bij het Instituut voor Strafrecht & Criminologie, en William Pridemore.

The department of Industrial Ecology is dealing with research into the development of tools for decision making on sustainable production and consumption.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.

De programmagroep Leer- en Gedragsproblemen in het Onderwijs doet onderzoek naar stagnaties die kunnen optreden in de cognitieve ontwikkeling.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Het Leiden Leadership Centre doet onderzoek naar de ontwikkeling van doeltreffend publiek leiderschap binnen en tussen organisaties. Op basis van onze onderzoeks- en ontwikkelagenda “Verder met Publiek Leiderschap” richten we ons op publiek leiderschap in verbinding met de publieke context, maatschappelijke…

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Consequences for sediment stability and seston trapping

Lees meer over de MSc International Politics aan Universiteit Leiden: programma-opbouw, kernvakken, thesis-seminar en kleinschalige begeleiding in Den Haag.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.