Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Hoogleraar Yiya Chen van de Universiteit Leiden deelt in NEMO Kennislink haar expertise over toontalen en hun wereldwijde verspreiding. Zo'n 40 tot 50 procent van alle talen is een toontaal.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

Promotor: Prof.dr. H.V.J. Linnartz

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Promotor: B.van de Water, Co-promotor: L.S.Price

Promotor: Prof.dr. G.P. van Wezel

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Anders dan Nederlands en Engels gebruiken de meeste talen melodie doorgaans niet alleen om zinsbetekenis te nuanceren maar ook om woorden van elkaar te onderscheiden. Hoe talen dit doen, is goeddeels onbekend. Dit project onderzoekt daarom de taalkundige, psychologische en hersenprocessen achter deze…

Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Een goede taalontwikkeling is van belang voor de cognitieve en sociale ontwikkeling, om te kunnen communiceren en om te kunnen leren. Als de taalontwikkeling niet verloopt zoals verwacht, kan dit allerlei consequenties hebben. Kinderen met een extra X of Y chromosoom hebben een verhoogd risico op problemen…

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Op 19 september 2019 verdedigde Lynette Janssen zijn proefschrift 'EU Bank Resolution Framework: A comparative study on the relation with national private law'. Het promotieonderzoek is begeleid door promotoren prof.mr. W.A.K. Rank en prof.mr. M. Haentjens.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Centraal in dit proefschrift staan de perspectieven van docenten met betrekking tot zelfstandig leren.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

Including modelling as part of software development appears to have various benefits.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

Op 10 juni 2021 verdedigde Merinda Stewart haar proefschrift 'Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace'. Het promotieonderzoek is begeleid door promotoren prof.dr. P.M.J. Mendes de Leon en prof.dr. J.J. Rijpma.

Op 26 september promoveert Cosmas Rai Amenorvi. Het Leiden University Centre for Linguistics feliciteert Cosmas!

Lezing, Lezingenreeks vergelijkende Indo-Europese taalwetenschap (VIET)

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Een vergelijkende analyse van legitimeringsstrategieën in drie landen: Rusland, Venezuela en de Seychellen.

In dit artikel heeft Lianne Visser bijgedragen aan het begrip rondom samenwerkend bestuur als uitdagende aanpak voor hardnekkige problemen.

On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.

The demand for neodymium-iron-boron (NdFeB) magnets is rapidly growing, while the neodymium supply chain is under pressure. Recycling can alleviate these issues. This thesis investigates the potential for deploying novel magnet recycling technologies and their environmental consequences.

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

Hoe beheren humanitaire responsorganisaties (HRO's) en virtuele en technische gemeenschappen (V&TC's) gezamenlijk de processen voor het bepalen van de betekenis van rampen, en welke uitdagingen vormen de effectiviteit van deze samenwerkingen tussen 2010 en 2016?

Promotie

Promotie