Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Op 18 september 2019 verdedigde Huw Llewellyn zijn proefschrift 'An Institutional Perspective on the United Nations Criminal Tribunals: Governance, Independence and Impartiality'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.M. Blokker en prof.dr. L.J. van den Herik.

Leidse wetenschappers doen onderzoek naar de ontwikkeling van veilige vaccins tegen corona.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Promotor: W. Jiskoot, Co-promotor: H.A. Every

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

De collectie Visuele Etnografie van de Universiteit Leiden is toegevoegd aan Alexander Street Press, een educatieve streaming video service. De masterspecialisatie Visuele Etnografie heeft inmiddels al veel getalenteerde studenten ondersteund bij het produceren van inspirerende films. Ongeveer 70…

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

Promotor: Prof.dr. H.J.A. Rottgering

When observing star-forming galaxies, we are not only seeing stellar light, but we also see how this interacts with galactic gas and dust. This thesis contains studies of the stellar, nebular and dust properties of low mass star-forming galaxies.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

Promotores: H.A. Udo De Haes, P.M. Brakefield

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

Promotor: P.D. Grünwald

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Green hydrogen is produced via a process called water electrolysis. During electrolysis water is split into oxygen and hydrogen.

Bega je een misdrijf, dan krijg je een passende straf; elke rechtsstaat kent dat uitgangspunt. Maar wat zijn precies rechtvaardige en effectieve straffen?Leidse onderzoekers geven nieuwe informatie en inzichten over straffen aan politici, wetgevers, handhavers en het publiek.

Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh

Wiskundige Gonny Hauwert (33) is een van de mentoren in het Mentornetwerk van de Universiteit Leiden. Via verschillende banen kwam ze erachter wat ze echt leuk vond. En dat bleek data-analyse. ‘Mijn ervaringen kunnen studenten helpen.’

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Professor Dirk Vandewalle is een internationaal veelgevraagde en gerenommeerde Libië-expert. In deze lezing gaat hij in op twee essentiële vragen over de huidige situatie in Libië. Hoe komt het dat het Libische politieke systeem zo fragiel geworden is? En hoeveel hoop is er nog dat Libië als eenheid…