Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.

Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…

Als groep verzorgen we ook onderwijs binnen het instituut Pedagogische Wetenschappen.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Het Laboratorium voor Archeologische Studies is een geavanceerd laboratorium met geavanceerde Leica stereomicroscopen en meetinstrumenten en een uitgebreide referentiecollectie die wordt gebruikt voor onderzoek naar bijvoorbeeld de identificatie van fossiele resten. De collectie wordt ook gebruikt om…

Sheltering is an immediate human need and determines well-being andhealth.

Promotor: Prof.dr. M. Ubbink

Een onderzoek naar de ontwikkeling van prosociaal gedrag.

Promotor: K.H. Kuijken

Dit project beoogt de ontwikkeling van geavanceerde data-analysemethoden voor monitoring en het vergroten van ons inzicht in de dynamiek van de biodiversiteit in natuurgebieden zoals de Oostvaardersplassen.

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

Als we een tekst lezen denken we te weten wie hem geschreven heeft, maar in de vroegmoderne periode was de productie van manuscripten vaak een gezamenlijke of 'gesocialiseerde' onderneming met secretarissen en schrijvers die fysiek schreven wat de auteur dicteerde.

Promotor: Prof.dr. H.L.V. Linnartz

The use of increasingly large and diverse datasets to guide urban climate action has implications for how, and by whom, local governments are held accountable.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

This thesis introduces the concept of

The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.

Kan gedrag in een online economisch spel worden begrepen als een representatie van radicaliseringsneiging?

In this PhD study, I aim to deepen our understanding of the influence of major mycorrhizal types, namely arbuscular mycorrhizae (AM) and ectomycorrhizae (EM), on the global soil carbon cycle and their potential distribution changes under future environmental shifts.

Het Research Lab for the Study of Heritage Languages of the Netherlands (HERLING) is een platform voor onderzoek naar erfgoedtalen die in Nederland worden gesproken, met een focus op Turks, Bahasa Indonesia, Spaans, Papiamento, Berbers, Arabisch en Duits. HERLING wil een brug slaan tussen wetenschappelijk…

CT scanning of skeletal remains can tell us about how strong or weak a persons bones were and we can relate that back to diet, activity, and reproductive factors.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Vergeten Afkomsten onderzoekt hoe generaties van tot slaaf gemaakten en hun nakomelingen hun slavernijverleden onder Nederlands en Brits bewind vergaten en lokale burgers werden in Sri Lanka en Zuid-Afrika. Het kijkt naar waarom en hoe vergeten, in plaats van herinneren, de basis werd voor hun identiteit…

In this thesis, I investigated the neurogenetic properties of Neotropical bat species. Bats represent the second largest mammalian order (Chiroptera) in the world, with Neotropical bats constituting about 13% of the total number of bat species.

The research group Science Communication and Society aims to understand how science communication works to improve the interaction between science and society. Central themes are ‘Bridging the gap between experts and the general public’ and ‘Evaluating Science Communication’.

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Wekelijks gaat het in de media over organisaties en medezeggenschap. De achtergronden zijn boeiend, en de juridische aandachtspunten en uitdagingen zijn al even interessant. Het ontbrak aan een goed en actueel boek dat het gehele terrein van de medezeggenschap bestrijkt. Medezeggenschap in breed perspectief…

De Europese rechtszaal als politieke arena? Rechterlijke bemoeienis in politiek beladen zaken in het Europees asiel- en strafrecht.

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

Promotor: A.P.IJzerman Co-promotor: A. Bender

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Na 20 jaar politiehervorming blikken Jasper De Paepe en Marleen Easton terug en ontdekken wat we kunnen leren over partnerschappen tussen politie en wetenschap in België.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Overkleeft

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.