Interdisciplinaire onderwijs- en onderzoeksprojecten

INFLUEX onderzoekt de invloed van experts op het openbare beleid, met als doel hun rol in democratische beleidsvorming te definiëren, meten en verklaren

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Dit artikel geschreven door Marieke Liem & Alexander Kamprad onderzoekt de relatie tussen terrorisme en interpersoonlijk geweld. Ze voerden cross-nationale analyses uit over de effecten van mortaliteitscijfers voor het terrorisme op moordcijfers. Uit de resultaten bleek dat terrorisme sterk en positief…

Grensverleggend geschiedenis leren.

Leidinggeven op afstand vraagt om een aangepaste leiderschapsstijl.

eLaw onderzoekt de rol van het recht in de informatiemaatschappij: hoe kan het recht bijdragen aan een goede werking van informatie- en communicatietechnologie, en het gebruik ervan door burgers, bedrijven en overheden?

Hoe herstellen cellen hun beschadigde DNA – en wat gebeurt er als dat proces verstoord raakt en kanker ontstaat? Tijdens haar promotieonderzoek dook Sarah Moser in deze vragen en ontdekte verrassende inzichten die kunnen bijdragen aan betere kankerbehandelingen in de toekomst.

Een internationale commissie heeft het informatica onderzoek van alle Nederlandse universiteiten beoordeeld over de periode 2009-2014. Informatica in Leiden kreeg het 'hoogste' cijfer (een 1) voor maatschappelijke relevantie.

De recente inwijding van de Indiase Ayodhya-tempel door premier en Bharatiya Janata Party boegbeeld Narendra Modi roept belangrijke vragen op. Maakt secularisme plaats voor religieuze overheersing in de grootste democratie ter wereld? Hoe resoneert dit bij de cultureel diverse bevolking van India? France…

Op donderdag 14 juni 2018 vindt de lustrumeditie van de jaarlijkse bijeenkomst van het Landelijk Staatssteunnetwerk plaats. Het thema is ‘Staatssteun en Innovatie’. Paul Adriaanse is als lid van de stuurgroep van het Landelijk Staatssteunnetwerk medeorganisator van deze bijeenkomst.

Het Internationaal Gerechtshof heeft in een baanbrekende uitspraak geoordeeld dat landen verplicht zijn om het klimaat te beschermen. Klimaat- en mensenrechtenexpert Jolein Holtz vindt het Hof te vaag over de gevolgen voor toekomstige generaties. ‘Dit is een gemiste kans.’

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Promotores: F.H. van Lunteren, F.P. Israel

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Promotor: Prof.dr. J. Kuiper

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

With tomography it is possible to reconstruct the interior of an object without destroying.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

Tussen 1683 en 1795 werd Suriname bestuurd door de Sociëteit van Suriname, een samenwerkingsverband tussen het stadsbestuur van Amsterdam, de West-Indische Compagnie en de familie Van Aerssen van Sommelsdyck. Terwijl de hoogtijdagen van de Gouden Eeuw al voorbij waren bloeide Suriname gedurende het…

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Mycorrhizas are symbiotic associations between soil fungi and most plant species.

Promotor: G.P. van Wezel

Within the field of astronomy, understanding how galaxies grow and evolve from the Big Bang to the present day is a challenging and complex question.

Promotor: T.H. Oosterkamp

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

There is accumulating evidence for an increase in severe global drought events. In particular, Europe experienced several severe droughts in 2003, 2015, and 2018 (unprecedented in the past 2,110 years). Such droughts have caused serious and far-reaching impacts on terrestrial ecosystems.

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.