Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Promotor: A. Kros

This thesis investigates the contribution of quantum computers to machine learning, a field called Quantum Machine Learning. Quantum Machine Learning promises innovative perspectives and methods for solving complex problems in machine learning, leveraging the unique capabilities of quantum computers…

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Promotor: H.V.J. Linnartz

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Promotor: Prof.dr. E. F. van Dishoeck

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

To meet the rising demand for minerals driven by the global shift to clean energy technologies, ensuring responsible and resilient supply chains is critical. Minerals like cobalt, lithium, and nickel for batteries, neodymium and zinc for wind turbines, and indium for solar panels are essential.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Sustainable energy from wind and solar is most readily available near the sea.

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

Empirical Legal Studies in Leiden focuste op het bouwen van een interdisciplinaire gemeenschap van rechtsgeleerden en sociale wetenschappers die samen juridische vraagstukken onderzochten op het snijpunt van recht en gedrag, waarbij diverse soorten methoden werden gebruikt.

An interdisciplinary collection of the best international scholarship on Muslim youth.

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

Promotores: W. Jiskoot, F. Ossendorp

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Workshop

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Congres/symposium

MA History specialisation Governance of Migration and Diversity at Leiden University

Beelden van de Indonesische oorlog. Veel van dit materiaal is, naast foto's en verzamelingen van oral history, terechtgekomen in de collecties van het KITLV en uiteindelijk de Universitaire Bibliotheken Leiden. MA-studenten geschiedenis Sander van der Horst, Linde Lammers & Melle van Maanen inventariseerden…

Omdat het archief van de oude Nederlandse West-Indische Compagnie (WIC, 1621-1674) bijna helemaal is verdwenen, is er niet veel bekend over de schepen en bemanningen van deze compagnie. In dit project beginnen we met de reconstructie van basisinformatie door gebruik te maken van nieuwe digitale technieken…

Deze bundel onderzoekt hoe westerse landen historisch onderscheid hebben gemaakt tussen categorieën migranten - zoals arbeidsmigranten, vluchtelingen, gezinsmigranten en postkoloniale migranten. In de bijdragen, die Frankrijk, de Verenigde Staten, Turkije, Canada, Mexico, Nederland, Zweden en Denemarken…

De master Arts and Culture van de Universiteit Leiden biedt je een topniveau kwalificatie op maatwerk op het gebied van kunst en cultuur.

Congres/symposium

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Lezing

Research Internships of 15 ECTS are available in Medieval History at Utrecht University, from 2021-22 block 4 until 2023-24 block 3, for Research MA students.

Te dure boodschappen, plotseling uitbrekende ziekten: vanaf de zestiende tot de negentiende eeuw doen honderden mensen verslag van de wereld om hen heen in kronieken. Een groot deel van deze teksten is de afgelopen jaren gedigitaliseerd. Hoogleraar Vroegmoderne Nederlandse Geschiedenis en projectleider…

Met een recent gepresenteerd groot onderzoek en de tentoonstelling van het Rijksmuseum, staat de onafhankelijkheidsstrijd van Indonesië weer volop in de belangstelling. Ook de Universiteit Leiden besteedt aandacht aan dit onderwerp. Geschiedenisstudenten Sander van der Horst en Melle van Maanen maakten…