7,421 zoekresultaten voor “Research” in de Publieke website
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Speciaal basisonderwijs en autisme
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School dropout among immigrant students: Types of dropout and predictors
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Securing the integrity of financial markets in times of crisis
Het Hazelhoff Centre for Financial Law onderzoeksprogramma voor 2020-20203 draait om de integriteit van financiële markten in tijden van crisis en de mogelijke manieren om deze integriteit te bewerkstelligen.
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Design and synthesis of next generation carbohydrate-mimetic cyclitols: towards deactivators of inverting glycosidases and glycosyl transferases
Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.
- Forensische gezinspedagogiek en jeugdhulpverlening lab
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Regulators of integrin α6β4 function
This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.
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Pre- and perinatal risk factors
Effects of maternal smoking, premature birth, intra-uterine growth retardation and asphyxia on child development.
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Extrasolar Planet Detection Through Spatially Resolved Observations
Promotor: I. Snellen, Co-Promotor: M. Kenworthy
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Delegation to Treaty Bodies and International Organisations for Conventional Arms Control Agreements in Europe
In dit artikel onderzoekt William Lippert hoe het overdragen van taken aan een uitvoerder van een overeenkomst van conventionele wapenbeheersing in Europa van invloed is op het succes ervan.
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Data Science Onderzoeksprogramma
Het Data Science Onderzoeksprogramma (DSO) is een universiteitsbreed programma dat erop gericht is de kwaliteit van het bestaande data science-onderzoek te verhogen en het gebruik van data science-methoden te bevorderen bij alle faculteiten van de Universiteit Leiden.
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Disease, Signaling and Drug Targets
The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.
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Exploring the Versatility of Human β-Glucosidases and Related Glycosylated Metabolites with Novel Chemical Tools
Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.
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Connect & FAIRify: FAIRification of a high throughput metabolomics laboratory with FAIR Digital Objects
Webinar, Q&A, discussion
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BRASILIAE. Indigenous Knowledge in the Making of Science: Historia Naturalis Brasiliae (1648).
Investigating the intercultural connections that shaped practices of knowledge production in colonial Dutch Brazil.
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Public and Private Regulation of Financial Markets
How should jurisdictions, both on the national and on the supra-national level, handle the interaction between public and private law where it regards the regulation of financial markets?
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Connect & step up: Overview of the concrete actions to improve our local data repository service, DataverseNL, as a FAIR-enabling service
Webinar, Q&A, discussion
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Connect & Retain: Data retention, active digital preservation and trustworthy digital archives - A myth buster talk
Webinar, Q&A, discussion
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Eén-jaars oefeneffecten voorspellen cognitieve uitkomsten op lange termijn bij de ziekte van Parkinson
Tot wel 50% van de mensen met de ziekte van Parkinson ontwikkelt na verloop van tijd cognitieve achteruitgang; deze studie onderzoekt het gebruik van ‘oefeneffecten’ op neuropsychologische tests als een vroege voorspeller van cognitieve achteruitgang.
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Countering Jihadi Insurgencies in Africa: Repress, Resist & Reorder (COUNTERRR)
Hoe reageren de Afrikaanse landen Mali, Nigeria en Mozambique op gewapende jihadistische groeperingen in Afrika? Zien we verschillende patronen in repressie door de staat, weerstand van de gemeenschap en, in samenhang daarmee, de veiligheidssituatie in deze landen?
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Gemeenschappelijk labs
Gemeenschappelijke labs voor algemeen gebruik.
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Quantitative pharmacology approaches to inform treatment strategies against tuberculosis
Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.
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The Impact of Name Writing on Early Literacy
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The influence of an improved school library and individual feedback on reading motivation
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- Van werken naar helpen: geneesmiddelontwikkeling.
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Targeting of antigen-presenting cells with mannosylated conjugates
This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.
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Discovery and characterization of new glucosylated metabolites: pathophysiological consequences
Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.
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Adapt
Wat verklaart het verschil tussen succesvolle en minder succesvolle crisisreacties, en hoe kunnen deze lessen worden vertaald naar aanpassingsstrategieën die samenlevingen kunnen gebruiken om toekomstige crises het hoofd te bieden?
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Development of nanoparticulate adjuvants based on aluminium salts
The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.
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Teachers' use of progress data in planning and evaluating instruction for students with learning disabilities
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Software
Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements
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Bookstart: About an early start with books
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Innovative (electro-driven) sample preparation tools for metabolomics study of muscle aging
This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.
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De bevolkingsgeschiedenis van Zuid-Amerika herzien: multidisciplinaire perspectieven op de Boven-Amazone
Dit project onderzoekt de bevolkingsdynamiek in het westen van Zuid-Amerika op basis van sporen in de geografische, genetische, archeologische, etnologische en taalkundige gegevens.
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Synthesis of D-alanylated wall teichoic acids from staphylococcus aureus
This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.
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Cluster ADHD & Aggression
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Becoming Literate by Means of the internet
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- Leiden University Gender Equality Plan 2021
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GMP-faciliteit voor innovatieve geneesmiddelen (KFT-J10 / IGFL)
De GMP-faciliteit maaktde ontwikkeling en productie van Advanced Therapy Medicinal Products (ATMP's) en chemische (peptide) synthese mogelijk.
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Explaining Government–Opposition Voting in Parliament
Er is nogal wat variatie in de mate waarin parlementaire stemmingen verlopen volgens de scheidslijn regering-oppositie. Hoe zijn deze verschillen te verklaren? Party Politics artikel van Tom Louwerse et al.
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Onderzoeksfaciliteiten
Voor succes in onderzoek is toegang tot hoogwaardige onderzoeksfaciliteiten essentieel. Daarom stelt de Universiteit Leiden haar onderzoeksfaciliteiten beschikbaar voor onderzoekers uit het bedrijfsleven, kennisinstituten en universiteiten.
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Eindevaluatie Wet herziening kinderbeschermingsmaatregelen
Dit onderzoek evalueert de Wet herziening kinderbeschermingsmaatregelen die per 1 januari 2015 is ingevoerd.
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Historische grondslagen van opvoeding
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Development of visual span in Hebrew and Dutch-speaking prereaders
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Transition metal compounds with S/N-functionalized NHC ligands: structures, redox properties and electrocatalytic activity
The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.
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Identification of Therapeutic Targets and Antisense Oligonucleotide Mediated Exon Skipping Based Therapies in Arthritis
Promotor: G.J.B. van Ommen
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Inverse design of curvature-sensing antiviral peptides
Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.
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Challenges of New Media for the Development of Early Literacy Skills in Children at Risk
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Development of a academic monitoring system for students with learning problems in secondary school
Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years
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Flow Cytometry Core Facility (FCF)
In de Flow Cytometry Core Facility van het LUMC is alle onderzoeks- en diagnostische flowcytometrieapparatuur van het LUMC ondergebracht.
