Wat doen bestrijdingsmiddelen, bemesting of plastic met de waterkwaliteit? En hoe beïnvloeden wind en regen de data? Dat en meer onderzoeken de Leidse milieuwetenschappers in de 32 sloten van het Levend Lab.

Ooit was de spoorlijn van Kimberley naar Kambove in zuidelijk Afrika een teken van welvaart en vooruitgang. Inmiddels kenmerken de uitgeputte mijnsteden zich door verval en vervuiling. Hoogleraar Jan-Bart Gewald ontvangt een NWO L-beurs om te onderzoeken wat de langetermijngevolgen voor de wereld zi…

Universitair docent Pedagogische Wetenschappen Carlijn Bergwerff ontvangt van Stichting Universitas een beurs om een 'proof-of-principle-onderzoek' te doen naar de mogelijkheid tot het gebruik van Virtual Reality (VR) voor het behandelen van trauma bij kinderen en jongeren. In dit project komen de interesses…

Historicus en majoor bij de Landmacht Dion Landstra onderzocht voor zijn promotie de effectiviteit van waarnemers in vredesoperaties op de Balkan tussen 1991 en 1995. Welke risico's zijn aanvaardbaar voor het handhaven en brengen van vrede? Zijn promotie is op 28 september.

This dissertation revolves around the design and implementation of novel instrumentation and related measurement techniques, at the single molecule level, for use in biophysical research. Chapter 1 presents an introduction to the field of fluorescence-based single molecule measurements. In particular,…

Promotor: Prof.dr. M. Danhof

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

Promotor: Prof.dr. S. Haring

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

In this thesis, we study systems of electrons in which strong correlations give rise to emergent exotic physics.

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Tin electrodeposition applications have rapidly evolved in the past 25 years.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Promotor: M.T.M. Koper, Co-promotors: A.I. Yanson, L.B.F. Juurlink

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Green hydrogen is produced via a process called water electrolysis. During electrolysis water is split into oxygen and hydrogen.

Promotor: Roeland M.H. Merks

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Promotor: Prof.dr. M.L. van Hecke

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Promotor: J.W.M. Frenken

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

This PhD thesis concerns the topic of arithmetic geometry. We address three different questions and each of the questions in some way is about counting how big some set is or can be.

Promotores: E. van Dijk, G.R. de Snoo. Co-promotor: H. Staats

Promotores: J. Jonkers, K.E. de Visser

This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.