Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

De programmagroep Onderwijswetenschappen verzorgt onderwijs op het gebied van onderwijs, het leren en de ontwikkeling van leerlingen in de schoolcontext. Studenten worden aangemoedigd uitkomsten van wetenschappelijk onderzoek te gebruiken om hun mening over het onderwijsbeleid en de onderwijspraktijk…

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

LIBC PUBLIEKSDAG 'HUMAN POTENTIAL; OPTIMALISEER JEZELF, TRAIN JE HERSENEN' (in Dutch)

A sustainable resource management is an essential aspect to satisfy the current human needs without compromising the needs of future generations.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Lezing

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

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Promotor: B.van de Water, Co-promotor: L.S.Price

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

AI Labs zijn samenwerkingen van de Universiteit Leiden met externe partner zoals bedrijven, overheidsinstellingen en andere universiteit op het gebied van kunstmatige intelligentie. De Faculteit voor Wis-en Natuurkunde is uniek gesitueerd op het grootste Bioscience Park van Nederlands, en ligt direct…

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

In this work, we attempt to answer the question:

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Promotor: Prof.dr. B. van de Water

Control of infectious diseases poses continuous challenges for human health.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Plastics have become an integral part of modern society due to their versatility and durability.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Rob Goedemans (52) is informatiemanager bij de afdeling Informatisering & Facilitaire Zaken (IFZ) en lid van het decentraal crisisteam. Hij houdt zich bezig met het faciliteren van en informatievoorziening rondom afstandsonderwijs. We vroegen Rob hoe hij onze faculteit door deze hectische periode heen…

Lezing

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